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Professor Michael Themis
Professor - Gene Therapy and Genotoxicity

Heinz Wolff 235

  • Biosciences

Summary

Dr Themis is a Reader in the Department of Life Sciences СʪÃÃÊÓƵ London and an Honorary Lecturer at Imperial College, London. His research at Brunel concerns gene therapy efficacy and safety.

Founding Director of TestaVec Ltd - A brunel University spin-out company

Between 2015 and 2017 over 1800 gene therapy (GT) trials were initiated or approved worldwide. Large pharmaceutical companies including GSK, Novartis, Astra Zeneca and Pfizer are investing heavily in gene therapy virus technology and two new licensed products, ‘Glybera” (Uniqure) and Strimvelis (GSK) have now entered the market. Treatments for several genetic disorders are available including cancer, however, no standardised platform has been available to test safety, which is concerning following the development of leukaemia in several children treated for X-linked immunodeficiency by this therapy. Dr Themis has recently launched the first company that focusses on screening the safety of gene therapy. The technology developed and led by Dr Themis in collaboration with UCL, KCL, GeneWerk, Germany, the National Institute for Biological Standards and Control and NMI, Germany, won the SBRI InMutaGene CRACK-IT Challenge. This work, which was funded by the NC3Rs and sponsored by GSK and Novartis has generated the first human induced pluripotent stem cell (iPSc) based platform that evaluates the safety of gene therapy products. The intension is to use this technology prior to patient exposure as a pre-screening service that identifies patient tolerance to gene therapy and to profile vector side effects next to established reference standards. With IP filed, TestaVec Ltd, which is a spin-out of СʪÃÃÊÓƵ will support academics and industry alike to enter their products safety into the clinic.

Qualifications:

  • BSc: 1st class honours with СʪÃÃÊÓƵ London and University Prize
  • PhD: 1994 entitled “Insertional mutagenesis:experiences at the hprt locus”
  • Post Graduate Certificate in Learning and Teaching in Higher Education (PGCert)
  • Post Graduate Certificate in Intellectual Property Law (PGCert)

Training

Persuasion and Assertiveness - 2008

PgCert in Teaching - 2008

PgCert in Patent Law - 2010

Blackboard Learn - 2012

Biological Monitoring for Health and safety – HSE Buxton 2012

Introduction to the Principles and Practices of working at Containment Level 3 – HPA Porton Down 2013

Responsibility

Teaching Interests

Cancer genetics, Gene Therapy and Genotoxicity, Health and Safety and Intellectual Property law. He coordinates the Gene Therapy and Genomic Technologies modules to undergraduates.

Administration

Deputy Chair of the Animal Welfare and Ethics Review Body (AWERB) and supports the concordat for Openness on Animal Research. He also holds a PIL and PPL.

He is part of the Quality Assurance Group for PPL management

He coordinates the Biology at Brunel event each year.

Lead for gene therapy technologies in the Synthetic Biology theme in the Institute of Life Sciences  

Newest selected publications

Suleman, S., Fawaz, S., Roberts, T., Ellison, S., Bigger, B. and Themis, M. (2024) ''. Journal of Virological Methods, 325 (April 2024). pp. 1 - 9. ISSN: 0166-0934

Journal article

Suleman, S., Fawaz, S., Roberts, T., Bigger, B., Ellison, S. and Themis, M. (2022) 'An optimised protocol to generate high titre lentiviral vectors by extended HEK293T culture following transient transfection and suspension culture'.ESGCT 29th Annual Congress In collaboration with BSGCT. Edinburgh, UK. 25 - 14 October. Human Gene Therapy. pp. A103 - A103. ISSN: 1043-0342

Conference paper

Suleman, S., Payne, A., Bowden, J., Al Haque, S., Zhan, M., Fawax, S., et al. (2022) ''. Gene Therapy (Basingstoke), 29 (12). pp. 720 - 729. ISSN: 0969-7128

Journal article

Suleman, S., Schrubaji, K., Filippou, C., Ignatova, S., Hewitson, P., Huddleston, J., et al. (2021) ''. Journal of Virological Methods, 299. pp. 1 - 9. ISSN: 0166-0934

Journal article

Lucendo-Villarin, B., Rashidi, H., Alhaque, S., Fischer, L., Meseguer-Ripolles, J., Wang, Y., et al. (2019) ''. Journal of Visualized Experiments, 2019 (149). pp. 1 - 8. ISSN: 1940-087X

Journal article
More publications(91)

СʪÃÃÊÓƵ London
Kingston Lane
Uxbridge
Middlesex UB8 3PH

Tel: +44 (0)1895 274000

Fax: +44 (0)1895 232806

Security: +44 (0)1895 255786

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